Dyscrasied

1594, Dean Sutcliffe of Exeter, An Answere unto a certaine calumnious letter, “To the Reader”, page viii; quoted in:

A discourse in the opinion of wise men very preiudiciall both to her Maiesties authoritie and Lawes, and also to the peace of Gods church, and propagation of the Gospell, and certes very offensiue for diffaming of diuers honest men and loyall Subiects, and that before the Princes presence, which was not therein respected; and, to cease to speake much of a discourse so little worth, very vnsufficient and euilfeatured, beeing stuffed with many weake and false allegations, and much frivolous and idle talke as it were of a dyscrasied braine.

[…] a discrasyed body […]

These bodies are constant in malarial fevers of serious import. When this dyscrasied condition of the blood has existed for any considerable length of time, the result most generally is a chill, by which the vital action is lowered, and the action of the heart increased, but correspondingly diminshed in force.